Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501681 | 0.80 | ALDH1A1 (0.41) | ADORA2AADORA2BADORA1ALDH1A1MAPT | |
| SCHEMBL9197469 | 0.80 | HPGD (0.51) | ADORA2AADORA1CYP3A4ADORA3MEN1 | |
| SCHEMBL10559533 | 0.78 | P2RX3 (0.42) | ADORA3 | |
| SCHEMBL10741335 | 0.76 | ADORA2A (0.43) | ADORA2AADORA2BADORA1ALDH1A1MAPK1 | |
| SCHEMBL10562559 | 0.76 | KMT2A (0.47) | ADORA2AADORA2BADORA1ALDH1A1MAPT | |
| SCHEMBL10560334 | 0.75 | P2RX3 (0.43) | ADORA2BHPGD | |
| SCHEMBL10564399 | 0.75 | RGS4 (0.44) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL10559101 | 0.75 | P2RX3 (0.47) | ADORA2AADORA2BADORA1MAPTLMNA | |
| SCHEMBL10332847 | 0.74 | CYP1A2 (0.42) | ADORA2AALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL10557859 | 0.74 | ADORA3 (0.46) | ADORA3KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824848-A | TREATMENT, PREVENTION OF NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-25 | — | — | US | disclosed |