Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 12/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313747 | 1.00 | CASP1 (0.54) | CASP1CTRB1ATMTACR1CTSL | |
| SCHEMBL8458841 | 0.89 | CTRB1 (0.50) | CASP1CTRB1ATMTACR1CTSL | |
| SCHEMBL7296396 | 0.89 | CTRB1 (0.50) | CASP1CTRB1ATMTACR1CTSL | |
| SCHEMBL7418478 | 0.87 | TACR1 (0.55) | CASP1CTRB1TACR1CTSLCTSS | |
| SCHEMBL7298020 | 0.87 | CTRB1 (0.54) | CTRB1ATMTACR1CTSLCTSS | |
| SCHEMBL7300784 | 0.87 | CTRB1 (0.61) | CTRB1ATMTACR1CTSLCTSS | |
| SCHEMBL7172190 | 0.87 | CTRB1 (0.54) | CTRB1ATMTACR1CTSLCTSS | |
| SCHEMBL4598612 | 0.87 | CTRB1 (0.61) | CTRB1ATMTACR1CTSLCTSS | |
| SCHEMBL7169930 | 0.87 | CTRB1 (0.54) | CTRB1ATMTACR1CTSLCTSS | |
| SCHEMBL7310119 | 0.87 | CTRB1 (0.61) | CTRB1ATMTACR1CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863903-A | RENIN ENZYME INHIBITORS, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| US-4719288-A | HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1988-01-12 | — | — | US | disclosed |
| US-4613676-A | PEPTIDES | CIBA-GEIGY CORPORATION (US) | 1986-09-23 | — | — | US | disclosed |
| EP-0094815-A2 | Oligopeptide prodrugs | SMITHKLINE BECKMAN CORPORATION (US) | 1983-11-23 | — | — | EP | disclosed |