Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604677 | 0.88 | CTSD (0.48) | ALDH1A1HPGDKDM4ENPSR1ERN1 | |
| SCHEMBL27626385 | 0.86 | CA12 (0.50) | ALDH1A1HPGDKDM4ENPSR1ERN1 | |
| SCHEMBL7616763 | 0.86 | KDM4E (0.54) | ALDH1A1HPGDKDM4ENPSR1ERN1 | |
| SCHEMBL27697072 | 0.83 | CTSD (0.50) | ALDH1A1HPGDKDM4ENPSR1ERN1 | |
| SCHEMBL7471611 | 0.82 | ALDH1A1 (0.44) | ALDH1A1HPGDKDM4ENPSR1ERN1 | |
| SCHEMBL8967497 | 0.81 | KDM4E (0.51) | ALDH1A1HPGDKDM4ENPSR1MAPT | |
| SCHEMBL14134452 | 0.79 | CYP1A2 (0.45) | ALDH1A1HPGDKDM4ENPSR1ERN1 | |
| SCHEMBL21525442 | 0.79 | ALDH1A1 (0.43) | ALDH1A1HPGDKDM4ENPSR1ERN1 | |
| SCHEMBL3622482 | 0.79 | KMT2A (0.53) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL2770226 | 0.77 | KDM4E (0.42) | ALDH1A1HPGDKDM4ENPSR1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134616-A2 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-05 | — | — | WO | disclosed |
| US-20090257979-A1 | Novel Inhibitors of Hepatitis C Virus Replication | INTERMUNE, INC. (US) | 2009-10-15 | — | — | US | disclosed |
| US-20090257979-A1 | Novel Inhibitors of Hepatitis C Virus Replication | INTERMUNE, INC. (US) | 2009-10-15 | — | — | US | disclosed |
| US-4804679-A | INHIBIT CHOLESTEROL BIOSYNTHESIS | SANDOZ PHARM. CORP. (US) | 1989-02-14 | — | — | US | disclosed |
| US-4686237-A | LOWERING BLOOD CHOLESTEROL LEVEL | SANDOZ PHARMACEUTICALS CORP. (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0117228-A1 | Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals | SANDOZ AG (CH) | 1984-08-29 | — | — | EP | disclosed |
| WO-1984002903-A1 | MEVALONOLACTONE ANALOGS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | SANDOZ AG (CH) | 1984-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090257979-A1 | Novel Inhibitors of Hepatitis C Virus Replication | EIF2AK2, HAVCR2, HDGF | ALDH1A1 1614/4885HPGD 2930/4885KDM4E 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.