Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10564142 | 0.84 | KMT2A (0.43) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL10563076 | 0.80 | LMNA (0.30) | LMNASMN1; SMN2JAK2JAK1JAK3 | |
| SCHEMBL10565134 | 0.79 | GAA (0.40) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL10509852 | 0.71 | MEN1 (0.44) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL9296106 | 0.67 | KDM4E (0.47) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL11082963 | 0.64 | RAB9A (0.50) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL31679507 | 0.64 | ALDH1A1 (0.53) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL11163446 | 0.63 | ALDH1A1 (0.69) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL11162029 | 0.63 | ALDH1A1 (0.63) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL22857999 | 0.62 | KDM4E (0.46) | KMT2AMEN1PKMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | disclosed |
| EP-0193329-A2 | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-09-03 | — | — | EP | disclosed |