Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10563757 | 0.91 | MAPT (0.46) | MAPTMAOBALOX5FFAR1FFAR4 | |
| SCHEMBL10562286 | 0.86 | MAOB (0.51) | MAOBFFAR1FFAR4PTPN1TBXAS1 | |
| SCHEMBL10564870 | 0.83 | RXRA (0.61) | MAOBFFAR1PTPN1RXRANR1H2 | |
| SCHEMBL4415159 | 0.83 | TSHR (0.50) | MAOBALOX5FFAR1FFAR4TBXAS1 | |
| SCHEMBL10514703 | 0.82 | MAPK1 (0.48) | MAPTMAOBCYP4F2CYP4A11ALDH1A1 | |
| Methane SCHEMBL10565161 | 0.82 | TSHR (0.49) | MAOBALOX5FFAR1FFAR4TBXAS1 | |
| SCHEMBL10565958 | 0.80 | ALDH1A1 (0.46) | MAPTMAOBTBXAS1RXRAALDH1A1 | |
| SCHEMBL10567154 | 0.79 | MAOB (0.51) | MAOBFFAR1FFAR4TBXAS1ALDH1A1 | |
| SCHEMBL10564801 | 0.77 | MAOB (0.44) | MAPTMAOBALOX5TBXAS1CYP4F2 | |
| SCHEMBL4417759 | 0.76 | ALDH1A1 (0.48) | MAPTALOX5RXRAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4816591-A | 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives | AMERICAN HOECHST CORPORATION (US) | 1989-03-28 | — | — | US | disclosed |
| US-4585788-A | 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives | AMERICAN HOECHST CORPORATION (US) | 1986-04-29 | — | — | US | disclosed |
| US-4082850-A | TOPICAL APPLICATION OF A 6,11-DIHYDROBENZ(B,E)OXEPIN-ALKANOIC ACID OR DERIVATIVES THEREOF | AMERICAN HOECHST CORPORATION (US) | 1978-04-04 | — | — | US | disclosed |