Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 5/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 3/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.37 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.37 |
| ▸ | HIF1AN | Q9NWT6 | 3/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566652 | 0.85 | PDE4B (0.54) | GAAMAPTPDE5APDE4BKDM4E | |
| SCHEMBL10846042 | 0.82 | PDE4B (0.51) | GAAMAPTPDE5APDE4BKDM4E | |
| SCHEMBL11786604 | 0.81 | CCNE2 (0.48) | KDM6BKDM4CHCAR3GAAMAPT | |
| SCHEMBL10563817 | 0.80 | CYP3A4 (0.38) | HCAR3MAPTPDE5APDE4BCDK2 | |
| Acetic Acid SCHEMBL11790811 | 0.79 | CCNE2 (0.47) | KDM6BKDM4CHCAR3GAAMAPT | |
| SCHEMBL10563794 | 0.78 | HCAR3 (0.41) | HCAR3KDM4EALDH1A1RAB9A | |
| SCHEMBL2052464 | 0.72 | MEN1 (0.57) | HCAR3MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13544631 | 0.70 | KDM6B (0.33) | KDM6BKDM4CKDM4AKDM4DKDM3B | |
| SCHEMBL10567101 | 0.69 | HPGD (0.37) | HCAR3JAK2 | |
| SCHEMBL10570578 | 0.68 | CYP1A2 (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | disclosed |