Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 3/20 | 0.33 |
| ▸ | KDM4A | O75164 | 3/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.33 |
| ▸ | HIF1AN | Q9NWT6 | 3/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9073480 | 0.77 | DAPK3 (0.40) | PTK2PLK4CHEK1AURKADAPK3 | |
| SCHEMBL23629251 | 0.75 | KDM5A (0.50) | KDM4AKDM5BKDM5AKDM4C | |
| SCHEMBL10567882 | 0.72 | PTK2 (0.34) | PTK2PLK4CHEK1AURKADAPK3 | |
| SCHEMBL2112360 | 0.71 | CCNE2 (0.46) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL13544643 | 0.71 | KDM4E (0.38) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL10563794 | 0.70 | HCAR3 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL10565713 | 0.70 | KDM6B (0.44) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL10568643 | 0.70 | GRIN2D (0.38) | KDM4EALDH1A1HPGDASPHKDM8 | |
| SCHEMBL29696512 | 0.69 | PTK2 (0.33) | PTK2PLK4CHEK1AURKADAPK3 | |
| SCHEMBL5134164 | 0.66 | IL1B (0.45) | KDM6BKDM4AKDM4DGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |