Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10563794 | 0.88 | HCAR3 (0.41) | HCAR3 | |
| SCHEMBL10567519 | 0.87 | JAK3 (0.38) | HCAR3JAK2JAK1JAK3FGFR1 | |
| SCHEMBL10509852 | 0.84 | MEN1 (0.44) | HPGD | |
| SCHEMBL10568325 | 0.77 | MEN1 (0.32) | HCAR3 | |
| SCHEMBL10566676 | 0.74 | HPGD (0.33) | HPGD | |
| SCHEMBL10567882 | 0.70 | PTK2 (0.34) | HPGDFGFR1KDR | |
| SCHEMBL10565713 | 0.69 | KDM6B (0.44) | HCAR3JAK2 | |
| SCHEMBL10507536 | 0.67 | TGFBR1 (0.40) | HPGDHCAR3 | |
| SCHEMBL13544631 | 0.64 | KDM6B (0.33) | HPGDFGFR1KDR | |
| SCHEMBL10506617 | 0.62 | SLC2A1 (0.48) | HPGDINSRIGF1RFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | claimed |
| EP-0193329-A2 | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-09-03 | — | — | EP | claimed |
| US-4837238-A | Pharmacologically useful pyrazolopyridines | BEECHAM GROUP P.L.C. (GB) | 1989-06-06 | — | — | US | disclosed |
| EP-0193329-A2 | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-09-03 | — | — | EP | disclosed |