Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10733805 | 0.81 | PGR (0.35) | IDO1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL9830544 | 0.81 | PDE4A (0.51) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL9832544 | 0.78 | CHRNB2 (0.42) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9833850 | 0.78 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL10373859 | 0.76 | CHEK2 (0.49) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL10567045 | 0.71 | TLK2 (0.30) | — | |
| SCHEMBL10767730 | 0.70 | CHRNB2 (0.37) | ALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9832273 | 0.70 | PDE4A (0.48) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL10372601 | 0.69 | PDE2A (0.36) | KDM4ETP53PDE3BPDE3A | |
| SCHEMBL10373839 | 0.69 | CYP17A1 (0.40) | KDM4EALDH1A1HPGDRAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |