Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 6/20 | 0.35 |
| ▸ | PDE4A | P27815 | 6/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833683 | 0.78 | PDE3B (0.46) | PDK2PDK4ATAD2PGRPDE4A | |
| SCHEMBL10566335 | 0.78 | ALDH1A1 (0.49) | HSD17B10MAPTPDK2PDK4ATAD2 | |
| Water SCHEMBL10471047 | 0.77 | PDE3B (0.45) | PDK2PDK4ATAD2PGRPDE4A | |
| SCHEMBL10701189 | 0.77 | HSD17B10 (0.41) | HSD17B10MAPTHDAC2HDAC8HDAC6 | |
| SCHEMBL9835356 | 0.75 | ATAD2 (0.46) | PDK2PDK4ATAD2PGRPDE4A | |
| SCHEMBL10695728 | 0.74 | MAPT (0.39) | HSD17B10MAPTHDAC2HDAC8HDAC6 | |
| SCHEMBL9833110 | 0.74 | GSK3B (0.46) | HSD17B10PDK2PDK4ATAD2PGR | |
| SCHEMBL9834972 | 0.73 | ATAD2 (0.50) | PDK2PDK4ATAD2PGRPDE4A | |
| SCHEMBL9835634 | 0.73 | ATAD2 (0.44) | PDK2PDK4ATAD2PGRPDE4A | |
| SCHEMBL10668135 | 0.72 | ATAD2 (0.43) | PDK2PDK4ATAD2PGRPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4695567-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-22 | — | — | US | disclosed |
| EP-0189103-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1986-07-30 | — | — | EP | disclosed |