Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10701189 | 0.91 | HSD17B10 (0.41) | MAPTHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL10693769 | 0.82 | MAPT (0.39) | MAPTHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL10695367 | 0.80 | KDM4E (0.42) | MAPTKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL10697005 | 0.77 | ALDH1A1 (0.41) | MAPTHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL10696397 | 0.75 | ALDH1A1 (0.40) | MAPTHSD17B10KMT2AALDH1A1HPGD | |
| SCHEMBL10567136 | 0.74 | HSD17B10 (0.45) | MAPTHSD17B10HDAC2HDAC8HDAC6 | |
| SCHEMBL10695723 | 0.74 | LMNA (0.44) | MAPTKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL10695201 | 0.73 | SCN9A (0.35) | MAPTKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL10693698 | 0.72 | KDM4E (0.40) | HSD17B10ALDH1A1KDM4ESCN9A | |
| SCHEMBL10696477 | 0.72 | KDM4E (0.42) | MAPTHSD17B10KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |