Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 3/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3025365 | 0.73 | MAOA (0.55) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL3791624 | 0.73 | MAOA (0.48) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL28962404 | 0.70 | MAOA (0.49) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL74720 | 0.70 | MEN1 (0.71) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL29992449 | 0.70 | MEN1 (0.71) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL19884908 | 0.70 | LTA4H (0.56) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL8047856 | 0.69 | AHR (0.46) | LTA4HAHRNR4A2CYP2A6F7 | |
| SCHEMBL12250943 | 0.69 | LTA4H (0.51) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL19884909 | 0.69 | LTA4H (0.51) | MAOAMEN1POLBMAPK1KMT2A | |
| SCHEMBL7062445 | 0.69 | MTNR1A (0.31) | SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824852-A | Substituted indole compounds which have useful effects on the central nervous system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-04-25 | — | — | US | disclosed |
| US-4740602-A | Indole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-04-26 | — | — | US | disclosed |