Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | CTSG | P08311 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15610987 | 0.82 | EGLN1 (0.57) | POLBEGLN1L3MBTL1GAAALDH1A1 | |
| SCHEMBL11250926 | 0.80 | ATAD2 (0.44) | POLBALDH1A1CYP1A2SMN1; SMN2CHRM1 | |
| SCHEMBL14253731 | 0.77 | HTR6 (0.63) | POLBL3MBTL1GAACYP1A2CYP2C9 | |
| SCHEMBL290791 | 0.77 | POLB (0.70) | POLBL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL18362074 | 0.77 | SCN9A (0.44) | POLBEGLN1L3MBTL1CHRM1 | |
| SCHEMBL11063088 | 0.77 | HTR1A (0.40) | L3MBTL1GAADRD2 | |
| SCHEMBL10688767 | 0.76 | POLB (1.00) | POLBL3MBTL1GAAALDH1A1CYP1A2 | |
| SCHEMBL29880432 | 0.76 | POLB (1.00) | POLBL3MBTL1GAAALDH1A1CYP1A2 | |
| SCHEMBL7289981 | 0.76 | OPRM1 (0.60) | DRD2CHRM3DRD4DRD3 | |
| Bicarbonate SCHEMBL25171118 | 0.76 | POLB (0.64) | POLBL3MBTL1GAAALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824840-A | ANTIHISTAMINES, NERVOUS SYSTEM CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| US-4734416-A | ANTIHISTAMINES, CENTRAL NERVOUS SYSTEM CONTROLLING ACTION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| US-4329468-A | ADRENERGIC BLOCKING AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-05-11 | — | — | US | disclosed |
| US-4256890-A | ADRENERGIC BLOCKING AGENTS | OTSUKAPHARMACEUTICAL CO., LTD. (JP) | 1981-03-17 | — | — | US | disclosed |
| US-4065456-A | CNS DEPRESSANTS | OTSUKA PHARMACEUTICAL CO., LTD. (JA) | 1977-12-27 | — | — | US | disclosed |