SCHEMBL10568290

SCHEMBL10568290

CC[Si](C)(Oc1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 5/20 0.36
CA4 P22748 1/20 0.36
CHRNB2 P17787 2/20 0.33
CHRNB4 P30926 2/20 0.33
CHRNA3 P32297 2/20 0.33
CHRNA7 P36544 2/20 0.33
CHRNA4 P43681 2/20 0.33
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
TSHR P16473 1/20 0.33
KCNA3 P22001 1/20 0.33
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
KCNH2 Q12809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15249587 0.80 ESR1 (0.37) LTA4HESR1ESR2KDM4ENPC1
SCHEMBL702493 0.78 LTA4H (0.39) LTA4HCA4CHRNB2CHRNB4CHRNA3
SCHEMBL837628 0.78 ESR1 (0.35) LTA4HCA4ESR1ESR2TSHR
SCHEMBL704142 0.77 LTA4H (0.38) LTA4HCA4CHRNB2CHRNB4CHRNA3
SCHEMBL3481625 0.77 ESR1 (0.34) LTA4HESR1ESR2TSHRKDM4E
SCHEMBL704611 0.77 LTA4H (0.38) LTA4HCA4CHRNB2CHRNB4CHRNA3
SCHEMBL11680664 0.77 TP53 (0.37) ESR1ESR2KDM4ENPC1ALDH1A1
SCHEMBL13089613 0.76 KCNA3 (0.32) LTA4HCA4KCNA3HTR1B
SCHEMBL19816761 0.76 LTA4H (0.40) LTA4HCA4CHRNB2CHRNB4CHRNA3
SCHEMBL1609541 0.76 LTA4H (0.40) LTA4HCA4CHRNB2CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4831091-A USING A COORDINATION CATALYST CONTAINING A SILANETRIOL OR -DIOL AS WELL AS AN AROMATIC ESTSER; ODORLESS; STEREOSPECIFIC; PARTICLE SIZES CHISSO CORPORATION (JP) 1989-05-16 US disclosed