Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.48 |
| ▸ | OXTR | P30559 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145336 | 0.84 | ALDH1A1 (0.51) | POLBHSD17B10HPGDAVPR2OXTR | |
| Hydrochloric Acid SCHEMBL10572689 | 0.78 | POLB (0.55) | POLBHSD17B10STAT3HPGDAVPR2 | |
| SCHEMBL9367417 | 0.77 | POLB (0.67) | POLBHSD17B10STAT3HPGDAVPR2 | |
| SCHEMBL11274786 | 0.77 | POLB (0.53) | POLBHSD17B10STAT3HPGDAVPR2 | |
| SCHEMBL10652675 | 0.77 | POLB (0.73) | POLBHSD17B10STAT3AVPR2OXTR | |
| SCHEMBL11271380 | 0.75 | POLB (0.52) | POLBHSD17B10STAT3HPGDAVPR2 | |
| SCHEMBL10652857 | 0.75 | POLB (0.51) | POLBHSD17B10STAT3HPGDAVPR2 | |
| SCHEMBL10573458 | 0.75 | POLB (0.51) | POLBHSD17B10STAT3AVPR2AVPR1A | |
| SCHEMBL1858987 | 0.74 | HSD11B1 (0.65) | POLBHSD17B10P2RX1HSD11B1 | |
| SCHEMBL10570434 | 0.74 | POLB (0.50) | POLBHSD17B10STAT3HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845099-A | ANTIARRHYTHMIA AGENTS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1989-07-04 | — | — | US | disclosed |
| EP-0263480-A1 | Tetrahydroquinoline derivatives, method for their preparation, their use and pharmaceutical compositions containing them | CASSELLA Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |
| EP-0025864-B1 | TETRAHYDROQUINOLINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, THEIR USE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | CASSELLA Aktiengesellschaft (DE) | 1983-05-18 | — | — | EP | disclosed |
| US-4335123-A | HYPOTENSIVE AGENTS, ANTIARRHYTHMIA AGENTS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1982-06-15 | — | — | US | disclosed |
| EP-0025864-A1 | Tetrahydroquinoline derivatives, processes for their production, their use and pharmaceutical preparations containing them | CASSELLA Aktiengesellschaft (DE) | 1981-04-01 | — | — | EP | disclosed |