Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.46 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472519 | 0.85 | ALDH3A1 (0.47) | ALDH1A1CTRB1ALDH3A1ALDH2PDE5A | |
| SCHEMBL2373229 | 0.82 | CES1 (0.63) | ALDH1A1ALDH3A1ALDH2PDE5AACHE | |
| SCHEMBL11318312 | 0.81 | LMNA (0.49) | ALDH1A1LMNAL3MBTL1MAPTTP53 | |
| SCHEMBL27506309 | 0.80 | CES1 (0.60) | ALDH1A1ALDH3A1ALDH2PDE5AACHE | |
| SCHEMBL27703276 | 0.80 | ALDH1A1 (0.76) | ALDH1A1LMNAALDH3A1ALDH2MAPT | |
| SCHEMBL4694440 | 0.79 | CTRB1 (0.71) | ALDH1A1CTRB1L3MBTL1MAPTKDM4E | |
| SCHEMBL10658852 | 0.77 | ALDH3A1 (0.44) | ALDH1A1ALDH3A1ALDH2PDE5AACHE | |
| SCHEMBL18954676 | 0.76 | ALDH1A1 (0.56) | ALDH1A1LMNAL3MBTL1ALDH3A1ALDH2 | |
| SCHEMBL4709524 | 0.74 | MAPT (0.60) | ALDH1A1LMNAL3MBTL1MAPTTP53 | |
| SCHEMBL1022200 | 0.74 | MAPT (0.60) | ALDH1A1LMNAL3MBTL1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1015459-B | QUINAZOLONE COMPOUND AND ITS PREPARATION METHOD | TANABE SEIYAKU CO (JP) | 1992-02-12 | — | — | CN | disclosed |
| US-4855298-A | 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2'5'-triones useful for the treatment and prophylaxis of diabetic complications | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-08 | — | — | US | disclosed |
| EP-0269378-A1 | Quinazolinone derivative and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1988-06-01 | — | — | EP | disclosed |
| CN-86107862-A | Quinazolinone compounds and preparation method thereof | — | 1988-05-25 | — | — | CN | disclosed |