Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370276 | 0.81 | CHRM4 (0.44) | HPGDPARP1KDM2BMEN1ALDH1A1 | |
| SCHEMBL1383189 | 0.72 | HPGD (0.60) | HPGDDRD2DRD3KDM4EMEN1 | |
| SCHEMBL29941526 | 0.69 | WDR5 (0.41) | HPGDKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL4463320 | 0.67 | ALDH1A1 (0.55) | HPGDKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL4860337 | 0.67 | GAA (0.50) | KDM2BKDM4EALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL29225521 | 0.67 | ELANE (0.41) | HPGDPARP1MEN1KMT2A | |
| SCHEMBL28242578 | 0.66 | NPC1 (0.54) | HPGDKDM4EALDH1A1KMT2A | |
| N-Methylpiperidine SCHEMBL11353667 | 0.65 | GAA (0.56) | PARP1KDM4EALDH1A1 | |
| SCHEMBL28227905 | 0.65 | PARP1 (0.55) | PARP1 | |
| SCHEMBL8355294 | 0.65 | GAA (0.51) | PARP1KDM2BKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4810795-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| US-4705853-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INC. (US) | 1987-11-10 | — | — | US | disclosed |
| US-4642343-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4604388-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof in a method of counteracting histamine | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-08-05 | — | — | US | disclosed |