Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.47 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10570872 | 0.90 | SIRT2 (0.50) | SIRT2CTSLSIRT5CTSSITGB3 | |
| SCHEMBL9500591 | 0.89 | SIRT2 (0.54) | SIRT2CTSLSIRT5CTSSITGB3 | |
| SCHEMBL5145708 | 0.89 | FOLH1 (0.59) | SIRT2CTSLSIRT5CTSSITGB3 | |
| SCHEMBL631840 | 0.89 | FOLH1 (0.59) | SIRT2CTSLSIRT5CTSSITGB3 | |
| SCHEMBL6768020 | 0.89 | FOLH1 (0.59) | SIRT2CTSLSIRT5CTSSITGB3 | |
| Water SCHEMBL7274005 | 0.88 | FOLH1 (0.58) | SIRT2CTSLSIRT5CTSSITGB3 | |
| Hydrochloric Acid SCHEMBL29401494 | 0.88 | FOLH1 (0.58) | SIRT2CTSLSIRT5CTSSITGB3 | |
| Hydrochloric Acid SCHEMBL333889 | 0.88 | FOLH1 (0.58) | SIRT2CTSLSIRT5CTSSITGB3 | |
| Hydrochloric Acid SCHEMBL333888 | 0.88 | FOLH1 (0.58) | SIRT2CTSLSIRT5CTSSITGB3 | |
| Bromide SCHEMBL9221277 | 0.88 | FOLH1 (0.58) | SIRT2CTSLSIRT5CTSSITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4870207-A | Synthesis of arphamenine A | Zaiden Hojin Biseibutsu Kagaku Kenkyu Kai (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0129163-B1 | ARPHAMENINE AND ITS RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) | 1987-09-16 | — | — | EP | disclosed |
| EP-0129163-A1 | Arphamenine and its related compounds, a process for their preparation and their use as medicaments | MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) | 1984-12-27 | — | — | EP | disclosed |