Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.57 |
| ▸ | ITGAV | P06756 | 2/20 | 0.57 |
| ▸ | TGM2 | P21980 | 9/20 | 0.53 |
| ▸ | CPB1 | P15086 | 1/20 | 0.52 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL631840 | 0.99 | FOLH1 (0.59) | FOLH1SIRT2SIRT1ITGB3ITGAV | |
| SCHEMBL5145708 | 0.99 | FOLH1 (0.59) | FOLH1SIRT2SIRT1ITGB3ITGAV | |
| SCHEMBL6768020 | 0.99 | FOLH1 (0.59) | FOLH1SIRT2SIRT1ITGB3ITGAV | |
| Water SCHEMBL7266301 | 0.98 | FOLH1 (0.58) | FOLH1SIRT2SIRT1ITGB3ITGAV | |
| Hydrochloric Acid SCHEMBL29401494 | 0.98 | FOLH1 (0.58) | FOLH1SIRT2SIRT1ITGB3ITGAV | |
| Water SCHEMBL7274005 | 0.98 | FOLH1 (0.58) | FOLH1SIRT2SIRT1ITGB3ITGAV | |
| Hydrochloric Acid SCHEMBL333889 | 0.98 | FOLH1 (0.58) | FOLH1SIRT2SIRT1ITGB3ITGAV | |
| Hydrochloric Acid SCHEMBL333888 | 0.98 | FOLH1 (0.58) | FOLH1SIRT2SIRT1ITGB3ITGAV | |
| SCHEMBL11411256 | 0.94 | CTSL (0.56) | FOLH1SIRT2SIRT1ITGB3ITGAV | |
| SCHEMBL9500591 | 0.92 | SIRT2 (0.54) | FOLH1SIRT2SIRT1ITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116829949-A | Compositions for detecting or measuring analytes | 伯蒂斯有限公司 | 2023-09-29 | — | — | CN | disclosed |
| WO-2023075435-A1 | COMPOSITION FOR DETECTING OR MEASURING ANALYTE | 주식회사 베르티스 | 2023-05-04 | — | — | WO | disclosed |
| US-20220283131-A1 | COMPOSITION FOR DETECTING OR MEASURING ANALYTES | BERTIS CO., LTD. (KR) | 2022-09-08 | — | — | US | disclosed |
| WO-2022050529-A1 | COMPOSITION FOR DETECTING OR MEASURING ANALYTE | ㈜베르티스 | 2022-03-10 | — | — | WO | disclosed |
| US-5399487-A | 6-peptidylamino-1-naphthalenesulfonamides useful as fluorogenic proteolytic enzyme substrates | HAEMATOLOGIC TECHNOLOGIES, INC. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0295316-A2 | Antitumor amino acid and peptide derivatives of 1,4-bis[ (aminoalkyl and hydroxyaminoalkyl)- amino]-5,8 dihydroxyanthraquinones | AMERICAN CYANAMID COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| US-4732970-A | Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones | AMERICAN CYANAMID COMPANY (US) | 1988-03-22 | — | — | US | disclosed |
| US-RE30473-E | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1981-01-06 | — | — | US | disclosed |