Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.70 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.69 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.66 |
| ▸ | PRKACA | P17612 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | WNT3A | P56704 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26884092 | 0.91 | SLC12A2 (0.64) | POLBELOVL1SLC12A2SLC12A5ROCK1 | |
| SCHEMBL19380614 | 0.83 | ELOVL1 (1.00) | ELOVL1SLC12A2SLC12A5ROCK1PRKACA | |
| SCHEMBL16440383 | 0.81 | NPC1 (0.59) | POLBSLC12A2SLC12A5ROCK1MAPT | |
| SCHEMBL15400878 | 0.80 | LMNA (0.73) | POLBMAPTMEN1KMT2ALMNA | |
| SCHEMBL225327 | 0.80 | ELOVL1 (0.74) | ELOVL1ROCK1PRKACAMAPTMEN1 | |
| SCHEMBL13357604 | 0.80 | ROCK1 (1.00) | ELOVL1ROCK1PRKACAMAPTMEN1 | |
| SCHEMBL13888016 | 0.79 | ROCK1 (0.80) | ROCK1MAPK1 | |
| SCHEMBL12303085 | 0.79 | WNT3A (0.90) | ELOVL1ROCK1PRKACAMAPTMEN1 | |
| SCHEMBL8402291 | 0.79 | MAPT (0.73) | ELOVL1SLC12A2SLC12A5MAPTMEN1 | |
| SCHEMBL1357607 | 0.79 | ELOVL1 (0.72) | ELOVL1ROCK1PRKACAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4877795-A | 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-10-31 | — | — | US | disclosed |
| EP-0277755-A1 | 4H-quinolizin-4-one compounds exhibiting therapeutic activities | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-08-10 | — | — | EP | disclosed |