Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 4/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10576643 | 0.85 | BACE1 (0.39) | ALDH1A1BACE1BACE2APPREN | |
| SCHEMBL10607948 | 0.81 | ALDH1A1 (0.38) | ALDH1A1GSK3AGSK3BSMN1; SMN2CNR1 | |
| SCHEMBL10570089 | 0.73 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2CNR1 | |
| SCHEMBL10576467 | 0.71 | BACE1 (0.43) | GSK3AGSK3BBACE1BACE2TSHR | |
| SCHEMBL10604466 | 0.71 | CNR1 (0.35) | ALDH1A1BACE1SMN1; SMN2CNR1GRIN1 | |
| SCHEMBL10576920 | 0.70 | MAOB (0.33) | ALDH1A1TSHRMAOAMAOBCNR1 | |
| SCHEMBL10570645 | 0.68 | ALDH1A1 (0.48) | ALDH1A1BACE1BACE2CTSDLMNA | |
| SCHEMBL10607870 | 0.67 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2CNR1 | |
| SCHEMBL10576456 | 0.67 | GSK3A (0.54) | ALDH1A1GSK3AGSK3BBACE1BACE2 | |
| SCHEMBL6537130 | 0.67 | ALDH1A1 (0.42) | ALDH1A1BACE1BACE2APPREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4883652-A | THICKEN EPIDERMIS, PROTECTIVE COATING, ANTIAGING | WELLA AKTIENGESELLSCHAFT (DE) | 1989-11-28 | — | — | US | disclosed |
| US-4746738-A | SKIN THICKENERS | WELLA AKTIENGESELLSCHAFT (DE) | 1988-05-24 | — | — | US | disclosed |
| EP-0116318-B1 | TETRAHYDRO-1,3-THIAZINE-2,4-DIONES, THEIR USE AND AGENTS CONTAINING THESE COMPOUNDS FOR THE TREATMENT OF THE SKIN | Wella Aktiengesellschaft (DE) | 1988-03-02 | — | — | EP | disclosed |
| EP-0116318-A1 | Tetrahydro-1,3-thiazine-2,4-diones, their use and agents containing these compounds for the treatment of the skin | Wella Aktiengesellschaft (DE) | 1984-08-22 | — | — | EP | disclosed |
| WO-1984003041-A1 | TETRAHYDRO-1,3-THIAZIN-2,4-DIONE, UTILIZATION THEREOF AND SKIN TREATING AGENTS CONTAINING SAID COMPOUND | WELLA AG (DE) | 1984-08-16 | — | — | WO | disclosed |