Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095085 | 0.77 | MEN1 (0.38) | PDE4BPDE4DMEN1HTTKMT2A | |
| SCHEMBL10570359 | 0.75 | HTR2C (0.42) | PDE4BPDE4DMEN1KMT2ALMNA | |
| SCHEMBL2273843 | 0.74 | LMNA (0.52) | PDE4BMEN1HTTKMT2ALMNA | |
| SCHEMBL2624086 | 0.74 | LMNA (0.56) | PDE4BMEN1HTTKMT2ALMNA | |
| SCHEMBL9384614 | 0.74 | TNKS (0.31) | PDE4BPDE4DTNKS2 | |
| SCHEMBL27851793 | 0.73 | TNKS2 (0.44) | PDE4BPDE4DMEN1HTTKMT2A | |
| Hydrochloric Acid SCHEMBL10574016 | 0.72 | PRKCI (0.47) | PDE4BPDE4DLMNATP53 | |
| SCHEMBL15659115 | 0.72 | PDE4B (0.42) | PDE4BPDE4D | |
| SCHEMBL10575470 | 0.72 | PDE4B (0.44) | PDE4BPDE4DMEN1KMT2ATP53 | |
| SCHEMBL11035315 | 0.70 | KDM4E (0.35) | PDE4BPDE4DTDP1TNKS2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4871739-A | Substituted 6H-7,8-dihydrothiapyrano(3,2-D)-pyrimidines as hyopglycemic agents | MERCK & CO., INC. (US) | 1989-10-03 | — | — | US | disclosed |