Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.53 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10576178 | 0.91 | NPBWR1 (0.46) | NPBWR1EGFRCHEK2HPSEHDAC6 | |
| SCHEMBL10578768 | 0.89 | ALDH1A1 (0.60) | NPBWR1EGFRCHEK2HDAC6TP53 | |
| SCHEMBL10574938 | 0.83 | MAPT (0.50) | MAPTSMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL10574680 | 0.83 | NPBWR1 (0.59) | NPBWR1EGFRCHEK2HPSEHDAC6 | |
| SCHEMBL10578228 | 0.81 | ALDH1A1 (0.55) | NPBWR1CHEK2HPSEHDAC6TP53 | |
| SCHEMBL10578748 | 0.80 | KDM4E (0.51) | HDAC6TP53MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10577479 | 0.80 | NPBWR1 (0.67) | NPBWR1EGFRCHEK2MMP2MMP9 | |
| SCHEMBL10575178 | 0.80 | METAP2 (0.42) | HDAC6TP53MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10579087 | 0.78 | KDM4E (0.52) | NPBWR1EGFRCHEK2HPSEHDAC6 | |
| SCHEMBL10695379 | 0.78 | KDM4E (0.51) | NPBWR1CHEK2HDAC6TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |