Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10576194 | 0.91 | NPBWR1 (0.58) | NPBWR1EGFRCHEK2HPSEHDAC6 | |
| SCHEMBL10578748 | 0.89 | KDM4E (0.51) | HDAC6KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10574919 | 0.83 | MTNR1A (0.40) | KDM4EALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL10574665 | 0.83 | NPBWR1 (0.47) | NPBWR1EGFRCHEK2HPSEHDAC6 | |
| SCHEMBL10576187 | 0.81 | NPBWR1 (0.46) | NPBWR1EGFRCHEK2HPSEHDAC6 | |
| SCHEMBL10578223 | 0.81 | KDM4E (0.47) | HPSEHDAC6KDM4EALDH1A1MAPT | |
| SCHEMBL10578768 | 0.80 | ALDH1A1 (0.60) | NPBWR1EGFRCHEK2HDAC6KDM4E | |
| SCHEMBL10577465 | 0.80 | NPBWR1 (0.53) | NPBWR1EGFRCHEK2HDAC6MMP2 | |
| SCHEMBL10575162 | 0.80 | MTNR1A (0.37) | HDAC6KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10574975 | 0.79 | SMN1; SMN2 (0.46) | CHEK2KDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |