Deferoxamine

SCHEMBL10579133

CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CS(=O)(=O)[O-].CS(=O)(=O)[O-].CS(=O)(=O)[O-].[Fe+3]

nearest known ligand 0.91

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BCR BRAF CHRM1 CHRNA10 CHRNA9 DRD1 DRD2 DRD3 DRD4 DRD5 EGFR F2 FLT1 FLT4 GCK GHSR GNRHR GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B HTR1A HTR1B HTR1D HTR2A HTR2C HTR3A IDH2 KDR KIT MAOB MCL1 MTTP P P4HB PDGFRB PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIKFYVE ROCK1 ROCK2 SLC18A2 SLC6A2 SLC6A3 SLC6A4 TACR1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 gyrA gyrB parC parE pol

The experimentally established mechanism targets of Deferoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

	gene	UniProt	supporting neighbours	confidence
▸	KDM4E	B2RXH2	1/20	0.91

▸	LMNA	P02545	1/20	0.91

▸	GAA	P10253	1/20	0.91

▸	SMN1; SMN2	Q16637	1/20	0.91

▸	KDM4A	O75164	9/20	0.84

▸	HIF1A	Q16665	1/20	0.84

▸	TET2	Q6N021	1/20	0.84

▸	DOHH	Q9BU89	1/20	0.84

▸	PAOX	Q6QHF9	2/20	0.39

▸	SLC6A5	Q9Y345	2/20	0.38

▸	KDM4C	Q9H3R0	8/20	0.35

▸	CASP2	P42575	1/20	0.33

▸	KDM5A	P29375	1/20	0.32

▸	KDM7A	Q6ZMT4	1/20	0.32

▸	PHF8	Q9UPP1	1/20	0.32

▸	KDM2A	Q9Y2K7	1/20	0.32

▸	CA1	P00915	1/20	0.32

▸	CA2	P00918	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Deferoxamine SCHEMBL18983317	0.98	KDM4E (0.91)	KDM4ELMNAGAASMN1; SMN2KDM4A
Deferoxamine SCHEMBL119983	0.98	KDM4E (0.91)	KDM4ELMNAGAASMN1; SMN2KDM4A
Deferoxamine SCHEMBL7715593	0.95	KDM4E (1.00)	KDM4ELMNAGAASMN1; SMN2KDM4A
Deferoxamine SCHEMBL1699778	0.95	KDM4E (1.00)	KDM4ELMNAGAASMN1; SMN2KDM4A
SCHEMBL30036991	0.95	KDM4E (1.00)	KDM4ELMNAGAASMN1; SMN2KDM4A
Deferoxamine SCHEMBL119982	0.95	KDM4E (1.00)	KDM4ELMNAGAASMN1; SMN2KDM4A
Deferoxamine SCHEMBL9351925	0.94	KDM4E (0.97)	KDM4ELMNAGAASMN1; SMN2KDM4A
Deferoxamine SCHEMBL3953046	0.94	KDM4E (0.97)	KDM4ELMNAGAASMN1; SMN2KDM4A
Deferoxamine SCHEMBL2165915	0.93	KDM4E (0.95)	KDM4ELMNAGAASMN1; SMN2KDM4A
Deferoxamine SCHEMBL1034134	0.93	KDM4E (0.95)	KDM4ELMNAGAASMN1; SMN2KDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4863716-A	PARAMAGNETIC MATERIAL FOR INJECTION	SALUTAR, INC. (US)	1989-09-05	—	—	US	disclosed