Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | VNN1 | O95497 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10578507 | 0.83 | L3MBTL1 (0.51) | MEN1KMT2ANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL10577438 | 0.82 | POLB (0.61) | SMN1; SMN2KDM4EHPGDNPC1RAB9A | |
| SCHEMBL10573017 | 0.82 | MEN1 (0.52) | MEN1KMT2ANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL4032340 | 0.81 | NPC1 (0.66) | SMN1; SMN2L3MBTL1NPC1RAB9AUSP2 | |
| SCHEMBL6283263 | 0.81 | RAB9A (0.66) | MEN1KMT2ASMN1; SMN2KDM4EHPGD | |
| SCHEMBL3628705 | 0.80 | HTT (0.68) | KMT2ASMN1; SMN2KDM4ELMNAL3MBTL1 | |
| SCHEMBL2142240 | 0.80 | RAB9A (0.58) | SMN1; SMN2NPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL10577883 | 0.80 | RAB9A (0.65) | MEN1KMT2ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL7079799 | 0.80 | L3MBTL1 (0.58) | KMT2ASMN1; SMN2KDM4ELMNAL3MBTL1 | |
| SCHEMBL28144225 | 0.80 | RAB9A (0.65) | KMT2ASMN1; SMN2KDM4ELMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108794385-A | A method of synthesis phenylethynylpyridin derivative | 陕西师范大学 | 2018-11-13 | — | — | CN | disclosed |
| US-4877795-A | 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-10-31 | — | — | US | disclosed |
| EP-0277755-A1 | 4H-quinolizin-4-one compounds exhibiting therapeutic activities | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-08-10 | — | — | EP | disclosed |