Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | LTA4H | P09960 | 1/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | PLAU | P00749 | 1/20 | 0.58 |
| ▸ | ELANE | P08246 | 1/20 | 0.58 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628705 | 0.92 | HTT (0.68) | NPC1ALDH1A1SMN1; SMN2MAPTUSP2 | |
| SCHEMBL28267555 | 0.88 | TDP1 (0.69) | NPC1ALDH1A1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL3299784 | 0.85 | NPC1 (0.62) | NPC1ALDH1A1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL11621845 | 0.84 | CTBP2 (0.63) | RAB9AUSP2CTBP2L3MBTL1 | |
| SCHEMBL28156355 | 0.83 | MAPT (0.55) | NPC1ALDH1A1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL10577487 | 0.83 | HTT (0.62) | NPC1ALDH1A1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL16320907 | 0.83 | ALDH1A1 (0.57) | NPC1ALDH1A1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL3175977 | 0.82 | HTT (0.61) | NPC1ALDH1A1SMN1; SMN2MAPTUSP2 | |
| SCHEMBL7153605 | 0.82 | HTT (0.61) | NPC1ALDH1A1SMN1; SMN2MAPTUSP2 | |
| SCHEMBL240822 | 0.82 | KDM4E (0.74) | NPC1ALDH1A1SMN1; SMN2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109046463-B | Bidentate aza-carbene-manganese catalyst, preparation method and alkylation synthesis application thereof | 中山大学 | 2021-05-04 | — | — | CN | disclosed |
| CN-107382640-B | β -aryl phenylpropanone compound synthesis method | 温州大学 | 2020-06-05 | — | — | CN | disclosed |
| CN-107382640-A | The synthetic method of β aryl phenylpropyl alcohol ketone class compounds | 温州大学 | 2017-11-24 | — | — | CN | disclosed |
| EP-1450777-B1 | PHARMACEUTICAL COMPOSITION CONTAINING CHALCONE OR ITS DERIVATIVES FOR MATRIX METALLOPROTEINASE INHIBITORY ACTIVITY | ANGIOLAB INC (KR) | 2013-05-08 | — | — | EP | disclosed |
| US-7572831-B2 | Composition containing chalcone | ANGIOLAB, INC. (KR) | 2009-08-11 | — | — | US | disclosed |
| US-20040209952-A1 | Composition containing chalcone | ANGIOLAB, INC. (KR) | 2004-10-21 | — | — | US | disclosed |
| US-4980508-A | Oxidation of 1,2-disulonyhydrazine compound with concentrated nitric acid | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-12-25 | — | — | US | disclosed |
| US-3947520-A | Compounds and process for preparing the same | THE UPJOHN COMPANY (US) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209952-A1 | Composition containing chalcone | MMP25, MMP13, MMP17 | NPC1 1463/4885ALDH1A1 2424/4885SMN1; SMN2 4416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.