Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | FGB | P02675 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813228 | 0.84 | SNCA (0.52) | NOX1MEN1MAPTMAPK1HTT | |
| SCHEMBL10591899 | 0.84 | NOX1 (0.43) | NOX1MEN1MAPTMAPK1HTT | |
| SCHEMBL10590497 | 0.80 | MAPT (0.45) | NOX1MEN1MAPTMAPK1HTT | |
| SCHEMBL10593297 | 0.69 | EPHX2 (0.47) | NOX1MEN1MAPTMAPK1HTT | |
| SCHEMBL10592030 | 0.66 | SNCA (0.44) | NOX1MEN1MAPTMAPK1HTT | |
| SCHEMBL10591060 | 0.64 | SNCA (0.55) | NOX1MEN1MAPTMAPK1HTT | |
| SCHEMBL1201818 | 0.64 | L3MBTL1 (0.45) | NOX1MEN1MAPTMAPK1HTT | |
| SCHEMBL10593152 | 0.63 | SNCA (0.52) | NOX1MEN1MAPTMAPK1HTT | |
| SCHEMBL9813116 | 0.60 | NOX1 (0.41) | NOX1MEN1MAPTMAPK1HTT | |
| SCHEMBL10591877 | 0.59 | EPHX2 (0.48) | NOX1MEN1MAPTMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115394-B1 | PHENOTHIAZONE DERIVATIVES AND ANALOGS | MERCK FROSST CANADA INC. (CA) | 1989-06-28 | — | — | EP | disclosed |
| EP-0155623-A2 | Use of lipoxygenase inhibitors for the preparations of cytoprotective pharmaceutical compostions and process for the preparation of a cytoprotective pharmaceutical composition | MERCK & CO. INC. (US) | 1985-09-25 | — | — | EP | disclosed |
| EP-0115394-A2 | Phenothiazone derivatives and analogs | MERCK FROSST CANADA INC. (CA) | 1984-08-08 | — | — | EP | disclosed |