Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10596825 | 0.85 | SMN1; SMN2 (0.63) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL9584535 | 0.77 | CYP1A2 (0.78) | NPC1RAB9ASMN1; SMN2NFKB1CYP1A2 | |
| SCHEMBL10595233 | 0.76 | RAB9A (0.66) | NPC1RAB9ASMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL6359975 | 0.74 | CYP1A2 (0.68) | NPC1RAB9ASMN1; SMN2NFKB1CYP1A2 | |
| SCHEMBL8202479 | 0.73 | RAB9A (0.71) | NPC1RAB9ASMN1; SMN2NFKB1CYP1A2 | |
| SCHEMBL10595285 | 0.72 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2TSHRKMT2A | |
| SCHEMBL11476769 | 0.72 | CYP1A2 (0.70) | NPC1RAB9ASMN1; SMN2NFKB1CYP1A2 | |
| SCHEMBL9491749 | 0.72 | HDAC3 (0.76) | NPC1RAB9ASMN1; SMN2NFKB1CYP1A2 | |
| SCHEMBL9585652 | 0.72 | CYP1A2 (0.70) | NPC1RAB9ASMN1; SMN2NFKB1CYP1A2 | |
| SCHEMBL10596231 | 0.71 | KMT2A (0.60) | NPC1RAB9ASMN1; SMN2CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560679-A | Organosilicon compounds and antitumor agents containing the compound as effective component | SANWA KAGAKU KENKYUSHO CO. LTD. (JP) | 1985-12-24 | — | — | US | claimed |
| EP-0109195-B1 | ANTITUMOR ORGANOSILICON COMPOUNDS AND THEIR PREPARATION | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-01-11 | — | — | EP | disclosed |
| US-4560679-A | Organosilicon compounds and antitumor agents containing the compound as effective component | SANWA KAGAKU KENKYUSHO CO. LTD. (JP) | 1985-12-24 | — | — | US | disclosed |
| EP-0109195-A2 | Antitumor organosilicon compounds and their preparation | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1984-05-23 | — | — | EP | disclosed |