Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10594665 | 0.85 | NPC1 (0.56) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL10595233 | 0.84 | RAB9A (0.66) | SMN1; SMN2RAB9ANPC1ALDH1A1CYP1A2 | |
| SCHEMBL9324910 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL18878471 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL14029065 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL22373763 | 0.80 | NAAA (0.65) | SMN1; SMN2LMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL4347123 | 0.78 | RAB9A (0.68) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL10484573 | 0.78 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNARAB9ANPC1RECQL | |
| SCHEMBL10595285 | 0.78 | NPC1 (0.64) | SMN1; SMN2LMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL15023510 | 0.78 | LMNA (1.00) | SMN1; SMN2LMNARAB9ANPC1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4560679-A | Organosilicon compounds and antitumor agents containing the compound as effective component | SANWA KAGAKU KENKYUSHO CO. LTD. (JP) | 1985-12-24 | — | — | US | claimed |
| EP-0109195-A2 | Antitumor organosilicon compounds and their preparation | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1984-05-23 | — | — | EP | claimed |
| JP-59070692-A | — | — | None | — | — | JP | disclosed |
| EP-0109195-B1 | ANTITUMOR ORGANOSILICON COMPOUNDS AND THEIR PREPARATION | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-01-11 | — | — | EP | disclosed |
| US-4560679-A | Organosilicon compounds and antitumor agents containing the compound as effective component | SANWA KAGAKU KENKYUSHO CO. LTD. (JP) | 1985-12-24 | — | — | US | disclosed |
| EP-0109195-A2 | Antitumor organosilicon compounds and their preparation | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1984-05-23 | — | — | EP | disclosed |
| JP-S5970692-A | NOVEL ORGANIC SILICON COMPOUND, ITS NON-TOXIC SALT, ITS PREPARATION AND ANTITUMOR AGENT CONTAINING SAID COMPOUND AS ACTIVE COMPONENT | SANWA KAGAKU KENKYUSHO:KK | 1984-04-21 | — | — | JP | disclosed |