Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 8/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | FASN | P49327 | 2/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10760941 | 0.83 | ALDH1A1 (0.46) | HPGDALDH1A1SMN1; SMN2L3MBTL1GABRA1 | |
| SCHEMBL20207163 | 0.81 | HSD17B3 (0.55) | HSD17B3HPGDALDH1A1ALOX15TSHR | |
| SCHEMBL7304310 | 0.79 | HPGD (0.57) | HSD17B3HPGDALDH1A1ALOX15TSHR | |
| SCHEMBL6727835 | 0.79 | HSD17B3 (0.53) | HSD17B3HPGDALDH1A1ALOX15TSHR | |
| SCHEMBL10600090 | 0.79 | HSD17B3 (0.53) | HSD17B3HPGDALDH1A1ALOX15TSHR | |
| SCHEMBL8092896 | 0.78 | GABRA1 (0.48) | ALDH1A1GABRA1GABRB2FASNPTGS1 | |
| SCHEMBL9417188 | 0.78 | ESR1 (0.53) | HSD17B3HPGDALDH1A1ALOX15TSHR | |
| SCHEMBL12232545 | 0.77 | HSD17B3 (0.55) | HSD17B3HPGDALDH1A1ALOX15TSHR | |
| SCHEMBL10497530 | 0.77 | HSD17B3 (0.55) | HSD17B3HPGDALDH1A1ALOX15TSHR | |
| SCHEMBL9417154 | 0.76 | ESR1 (0.51) | HSD17B3HPGDALDH1A1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173279-B1 | 2-(3,5-DIALKYL-4-HYDROXYPHENYL)INDOLE DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1989-08-23 | — | — | EP | disclosed |
| US-4695581-A | LIPOXYGENASE INHIBITOR | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1987-09-22 | — | — | US | disclosed |
| EP-0173279-A1 | 2-(3,5-Dialkyl-4-hydroxyphenyl)indole derivatives | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1986-03-05 | — | — | EP | disclosed |