Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.58 |
| ▸ | HTR1A | P08908 | 10/20 | 0.57 |
| ▸ | HTR7 | P34969 | 8/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11273684 | 0.82 | PARP1 (0.44) | PARP1HTR1AHTR7DRD2DRD4 | |
| SCHEMBL11065952 | 0.81 | PARP1 (0.53) | PARP1HTR1AHTR7DRD2DRD4 | |
| SCHEMBL8689425 | 0.79 | DRD4 (0.76) | PARP1HTR1AHTR7DRD2DRD4 | |
| SCHEMBL712211 | 0.78 | PARP1 (0.53) | PARP1HTR1AHTR7DRD2DRD4 | |
| SCHEMBL11844266 | 0.75 | PARP1 (0.70) | PARP1HTR1AHTR7PARP2 | |
| SCHEMBL11066340 | 0.75 | DRD3 (0.57) | PARP1HTR1AHTR7DRD2DRD4 | |
| SCHEMBL10601141 | 0.74 | PDE10A (0.55) | PARP1HTR1AHTR7DRD2DRD3 | |
| SCHEMBL11847564 | 0.70 | PARP1 (0.62) | PARP1HTR1AHTR7DRD2HTR2A | |
| SCHEMBL10602407 | 0.70 | HTR1A (0.44) | PARP1HTR1AHTR7DRD2DRD3 | |
| SCHEMBL11785894 | 0.70 | DRD2 (0.56) | PARP1HTR1ADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0155459-B1 | Use of some 2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-d]imidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases | GRUPPO LEPETIT S.p.A. (IT) | 1989-04-26 | — | — | EP | claimed |
| US-4594348-A | CARDIOTONIC AGENTS;PHYPTENSIVE AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1986-06-10 | — | — | US | claimed |
| EP-0155459-A1 | Use of some 2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-d]imidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases | GRUPPO LEPETIT S.p.A. (IT) | 1985-09-25 | — | — | EP | claimed |
| EP-0155459-B1 | Use of some 2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-d]imidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases | GRUPPO LEPETIT S.p.A. (IT) | 1989-04-26 | — | — | EP | disclosed |
| EP-0155459-B1 | Use of some 2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-d]imidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases | GRUPPO LEPETIT S.p.A. (IT) | 1989-04-26 | — | — | EP | disclosed |
| US-4594348-A | CARDIOTONIC AGENTS;PHYPTENSIVE AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1986-06-10 | — | — | US | disclosed |
| US-4594348-A | CARDIOTONIC AGENTS;PHYPTENSIVE AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1986-06-10 | — | — | US | disclosed |
| US-4594348-A | CARDIOTONIC AGENTS;PHYPTENSIVE AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1986-06-10 | — | — | US | disclosed |
| EP-0155459-A1 | Use of some 2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-d]imidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases | GRUPPO LEPETIT S.p.A. (IT) | 1985-09-25 | — | — | EP | disclosed |
| EP-0155459-A1 | Use of some 2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-d]imidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases | GRUPPO LEPETIT S.p.A. (IT) | 1985-09-25 | — | — | EP | disclosed |
| EP-0155459-A1 | Use of some 2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-d]imidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases | GRUPPO LEPETIT S.p.A. (IT) | 1985-09-25 | — | — | EP | disclosed |