Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 8/20 | 0.52 |
| ▸ | HTR7 | P34969 | 6/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10600153 | 0.81 | PARP1 (0.58) | PARP1HTR1AHTR7DRD4DRD2 | |
| SCHEMBL8689425 | 0.79 | DRD4 (0.76) | PARP1HTR1AHTR7DRD4DRD2 | |
| SCHEMBL11069704 | 0.74 | HTR1A (0.50) | PARP1HTR1AHTR7DRD2DRD3 | |
| SCHEMBL11069920 | 0.72 | RAB9A (0.58) | PARP1ALDH1A1NPC1GAARAB9A | |
| Hydrochloric Acid SCHEMBL27147314 | 0.71 | RAB9A (0.63) | PARP1HTR7HTR2AALDH1A1NPC1 | |
| SCHEMBL11066340 | 0.70 | DRD3 (0.57) | PARP1HTR1AHTR7DRD4DRD2 | |
| SCHEMBL9391392 | 0.69 | HRH3 (0.72) | HTR1AHTR7DRD4DRD2DRD3 | |
| SCHEMBL11064227 | 0.69 | HTR7 (0.52) | HTR1AHTR7DRD2DRD3HRH3 | |
| SCHEMBL10601141 | 0.69 | PDE10A (0.55) | PARP1HTR1AHTR7DRD2DRD3 | |
| SCHEMBL1706695 | 0.69 | RAB9A (0.53) | PARP1ALDH1A1NPC1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034249-B1 | NEW NAPHTHIMIDAZOLE AND NAPHTHOXAZOLE DERIVATIVES, THEIR PREPARATION, AND THEIR USE IN PHARMACEUTICALS | GRUPPO LEPETIT S.P.A. (IT) | 1984-10-24 | — | — | EP | disclosed |
| US-4461894-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1984-07-24 | — | — | US | disclosed |
| US-4360674-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1982-11-23 | — | — | US | disclosed |
| EP-0034249-A2 | New naphthimidazole and naphthoxazole derivatives, their preparation, and their use in pharmaceuticals | GRUPPO LEPETIT S.P.A. (IT) | 1981-08-26 | — | — | EP | disclosed |