Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 12/20 | 0.38 |
| ▸ | PPARA | Q07869 | 10/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15846953 | 0.80 | SLC6A3 (0.51) | RAB9A | |
| SCHEMBL10510382 | 0.78 | GAA (0.41) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL8403428 | 0.75 | METAP2 (0.47) | PKMALDH1A1RAB9A | |
| SCHEMBL10110920 | 0.75 | METAP2 (0.47) | PKMALDH1A1RAB9A | |
| SCHEMBL6025987 | 0.75 | HSD17B10 (0.39) | CYP1A2GAACYP2C9PKMCYP2C19 | |
| SCHEMBL27569694 | 0.72 | TDP1 (0.36) | CYP1A2CYP2C9CYP2C19TDP1MTNR1A | |
| SCHEMBL7753601 | 0.72 | MTNR1A (0.44) | CYP1A2CYP2C19PPARAMTNR1AMTNR1B | |
| SCHEMBL11500506 | 0.72 | MTNR1A (0.44) | CYP1A2CYP2C19PPARAMTNR1AMTNR1B | |
| SCHEMBL6098824 | 0.72 | TDP1 (0.41) | TDP1ALDH1A1 | |
| SCHEMBL6098832 | 0.72 | TDP1 (0.41) | TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175325-B1 | NEW 8-SUBSTITUTED NUCLEOSIDE AND PURINE DERIVATIVES, THE PROCESS FOR THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pierrel S.p.A. (IT) | 1989-03-15 | — | — | EP | disclosed |
| EP-0175325-A2 | New 8-substituted nucleoside and purine derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them | Pierrel S.p.A. (IT) | 1986-03-26 | — | — | EP | disclosed |