Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | PON1 | P27169 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10683188 | 0.89 | HSD17B3 (0.56) | HSD17B3ALDH1A1TSHRNPSR1LMNA | |
| SCHEMBL12435277 | 0.82 | SLC18A1 (0.52) | HSD17B3ALDH1A1TSHRNPSR1LMNA | |
| SCHEMBL15842227 | 0.81 | TSHR (0.66) | HSD17B3ALDH1A1TSHRNPSR1LMNA | |
| SCHEMBL10792047 | 0.79 | HSD17B3 (0.76) | HSD17B3ALDH1A1TSHRNPSR1LMNA | |
| SCHEMBL16629667 | 0.79 | PON1 (0.58) | HSD17B3ALDH1A1TSHRNPSR1LMNA | |
| SCHEMBL10603419 | 0.79 | ALDH1A1 (0.60) | HSD17B3ALDH1A1TSHRLMNAKDM4E | |
| SCHEMBL14424526 | 0.78 | GABRP (0.50) | LMNANQO1GABRPGABRDGABRA1 | |
| SCHEMBL15842598 | 0.78 | GABRP (0.50) | ALDH1A1LMNAKDM4EHSD17B10NQO1 | |
| SCHEMBL8372531 | 0.77 | HSD17B3 (0.62) | HSD17B3ALDH1A1TSHRNPSR1LMNA | |
| SCHEMBL13462293 | 0.75 | PTPN1 (0.50) | MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0185319-B1 | FLUORO COUMARINS AS ANTILYMPHOEDEMA AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1989-09-06 | — | — | EP | claimed |
| EP-0185319-A2 | Fluoro coumarins as antilymphoedema agents | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1986-06-25 | — | — | EP | claimed |
| EP-0185319-B1 | FLUORO COUMARINS AS ANTILYMPHOEDEMA AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1989-09-06 | — | — | EP | disclosed |
| US-4749798-A | ANTIINFLAMMATORY, ANTISWELLING | BOEHRINGER BIOCHEMIA ROBIN SPA (IT) | 1988-06-07 | — | — | US | disclosed |
| EP-0185319-A2 | Fluoro coumarins as antilymphoedema agents | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1986-06-25 | — | — | EP | disclosed |