Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9661011 | 0.81 | MAPT (0.78) | KMT2AMAPTLMNAL3MBTL1TSHR | |
| SCHEMBL8796397 | 0.79 | KMT2A (0.66) | KMT2AMAPTLMNAHSD17B10RAB9A | |
| SCHEMBL410820 | 0.79 | LMNA (1.00) | KMT2AMAPTLMNAL3MBTL1TSHR | |
| SCHEMBL18527818 | 0.78 | KMT2A (0.72) | KMT2AMAPTLMNAHSD17B10RAB9A | |
| SCHEMBL18527815 | 0.78 | KMT2A (0.72) | KMT2AMAPTLMNAHSD17B10RAB9A | |
| SCHEMBL9585233 | 0.76 | MEN1 (0.70) | KMT2AMAPTLMNAL3MBTL1TSHR | |
| SCHEMBL10608854 | 0.76 | KMT2A (0.73) | KMT2AMAPTLMNACYP2D6RAB9A | |
| SCHEMBL10605779 | 0.76 | KMT2A (0.66) | KMT2AMAPTLMNAHSD17B10RAB9A | |
| SCHEMBL9166449 | 0.76 | KMT2A (0.70) | KMT2AMAPTLMNATSHRCYP2D6 | |
| SCHEMBL10603968 | 0.76 | KMT2A (0.69) | KMT2AMAPTLMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4837305-A | Derivatives of β-adrenergic antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1989-06-06 | — | — | US | disclosed |
| US-4687873-A | Derivatives of β-adrenergic antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1987-08-18 | — | — | US | disclosed |
| EP-0117089-A1 | Beta-adrenergic antagonist compounds and derivatives of beta-adrenergic antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1984-08-29 | — | — | EP | disclosed |