Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10615382 | 0.86 | KDM4E (0.53) | HPGDALDH1A1KDM4EDRD2CA1 | |
| SCHEMBL10615410 | 0.82 | KDM4E (0.49) | HPGDALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL7909264 | 0.78 | ATM (0.52) | DRD2MAPTCA1CA2ACHE | |
| SCHEMBL10616615 | 0.77 | ATM (0.45) | HPGDALDH1A1DRD2CA1CA2 | |
| SCHEMBL10616759 | 0.76 | KDM4E (0.39) | HPGDALDH1A1KDM4EMAPTPOLB | |
| Carbamic Acid SCHEMBL7763164 | 0.76 | ATM (0.48) | DRD2MAPTCA1CA2ACHE | |
| SCHEMBL10617633 | 0.74 | ATM (0.36) | HPGDALDH1A1DRD2MAPTCA1 | |
| SCHEMBL10615355 | 0.74 | KDM4E (0.44) | HPGDALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL7741128 | 0.73 | ALDH1A1 (0.63) | HPGDALDH1A1KDM4EMAPTATM | |
| SCHEMBL3786131 | 0.70 | MTNR1A (0.68) | DRD2MAPTCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288477-A1 | 2,3-DIHYDRO-1H-PHENALENE-2-AMINO COMPOUNDS AS ANTI-PSYCHOTIC DRUGS | THE UPJOHN COMPANY (US) | 1988-11-02 | — | — | EP | disclosed |
| EP-0234113-A1 | 2,3-Dihydro-1H-phenalene-2-amino compounds as anti-psychotic drugs | THE UPJOHN COMPANY (US) | 1987-09-02 | — | — | EP | disclosed |
| WO-1987004153-A1 | 2,3-DIHYDRO-1H-PHENALENE-2-AMINO COMPOUNDS AS ANTI-PSYCHOTIC DRUGS | THE UPJOHN COMPANY (US) | 1987-07-16 | — | — | WO | disclosed |