Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10627386 | 0.85 | TP53 (0.47) | TP53THRBLMNAPOLBRXFP1 | |
| SCHEMBL10626314 | 0.85 | TP53 (0.47) | TP53THRBLMNAPOLBRXFP1 | |
| SCHEMBL10631622 | 0.78 | KDM4E (0.50) | TP53THRBLMNAPOLBRXFP1 | |
| SCHEMBL10629394 | 0.78 | ATM (0.47) | TP53THRBLMNAPOLBRXFP1 | |
| SCHEMBL6050631 | 0.77 | THRB (0.46) | TP53THRBLMNAPOLBRXFP1 | |
| SCHEMBL29577008 | 0.75 | ALDH1A1 (0.47) | TP53THRBLMNARXFP1GSK3B | |
| SCHEMBL22774580 | 0.75 | ALDH1A1 (0.47) | TP53THRBLMNARXFP1GSK3B | |
| SCHEMBL6669710 | 0.74 | LMNA (0.49) | LMNANPC1KMT2AGSK3B | |
| SCHEMBL29577405 | 0.74 | LMNA (0.49) | LMNANPC1KMT2AGSK3B | |
| SCHEMBL10626260 | 0.74 | TP53 (0.52) | TP53THRBLMNARXFP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4772614-A | QUINOLINOLS | THE BOOTS COMPANY (GB) | 1988-09-20 | — | — | US | disclosed |
| CN-86104611-A | The preparation method of therapeutical agent | — | 1988-01-27 | — | — | CN | disclosed |
| EP-0206616-A2 | Quinolones having antihypertensive activity | The Boots Company PLC (GB) | 1986-12-30 | — | — | EP | disclosed |