Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | MMP8 | P22894 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | REN | P00797 | 7/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | IL1RN | P18510 | 3/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10976755 | 1.00 | MMP9 (0.45) | MMP9MMP8MMP2RENOPRD1 | |
| SCHEMBL10981168 | 0.86 | REN (0.58) | MMP9MMP8RENIL1RNERAP2 | |
| SCHEMBL10980933 | 0.86 | MMP9 (0.45) | MMP9MMP8MMP2RENMMP14 | |
| SCHEMBL10976366 | 0.86 | REN (0.58) | MMP9MMP8RENIL1RNERAP2 | |
| SCHEMBL10633366 | 0.86 | REN (0.58) | MMP9MMP8RENIL1RNERAP2 | |
| SCHEMBL10636529 | 0.86 | REN (0.58) | MMP9MMP8RENIL1RNERAP2 | |
| SCHEMBL10522370 | 0.85 | REN (0.44) | MMP9MMP8MMP2RENERAP2 | |
| SCHEMBL10519920 | 0.85 | MMP2 (0.50) | MMP9MMP8MMP2REN | |
| SCHEMBL10520294 | 0.84 | REN (0.42) | MMP9MMP8MMP2RENIL1RN | |
| SCHEMBL10522694 | 0.84 | MMP9 (0.44) | MMP9MMP8MMP2RENMMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128762-B1 | NEW HYPOTENSIVE PEPTIDES, THEIR PREPARATION AND THEIR USE | SANKYO COMPANY LIMITED (JP) | 1988-06-08 | — | — | EP | disclosed |
| US-4548926-A | RENIN INHIBITOR | SANKYO COMPANY LIMITED (JP) | 1985-10-22 | — | — | US | disclosed |
| EP-0128762-A2 | New hypotensive peptides, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1984-12-19 | — | — | EP | disclosed |