Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.50 |
| ▸ | MMP9 | P14780 | 6/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.50 |
| ▸ | REN | P00797 | 13/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519796 | 0.90 | MMP9 (0.47) | MMP2MMP9MMP8RENMMP1 | |
| SCHEMBL10521511 | 0.89 | MMP2 (0.46) | MMP2MMP9MMP8REN | |
| SCHEMBL10522487 | 0.85 | MMP2 (0.51) | MMP2MMP9MMP8MMP1 | |
| Bromide SCHEMBL10976755 | 0.85 | MMP9 (0.45) | MMP2MMP9MMP8REN | |
| Bromide SCHEMBL10635874 | 0.85 | MMP9 (0.45) | MMP2MMP9MMP8REN | |
| SCHEMBL10522370 | 0.85 | REN (0.44) | MMP2MMP9MMP8RENMMP1 | |
| SCHEMBL10522694 | 0.84 | MMP9 (0.44) | MMP2MMP9MMP8REN | |
| SCHEMBL10520294 | 0.84 | REN (0.42) | MMP2MMP9MMP8REN | |
| SCHEMBL10521500 | 0.84 | REN (0.44) | MMP2MMP9MMP8REN | |
| SCHEMBL10898002 | 0.84 | MMP9 (0.44) | MMP2MMP9MMP8REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |