Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8815909 | 0.83 | HDAC1 (0.56) | HDAC1HDAC6NOTUMSIGMAR1ADRB2 | |
| SCHEMBL11045005 | 0.83 | HDAC1 (0.48) | HDAC1HDAC6PTGER4NOTUMMAOB | |
| SCHEMBL10639707 | 0.82 | SIRT2 (0.50) | HDAC1HDAC6KEAP1PTGER4 | |
| Hydrochloric Acid SCHEMBL10636985 | 0.82 | HDAC1 (0.47) | HDAC1HDAC6PTGER4NOTUMMAOB | |
| SCHEMBL10642489 | 0.81 | CCR2 (0.46) | HDAC1HDAC6KEAP1PTGER4 | |
| SCHEMBL5661589 | 0.77 | SIGMAR1 (0.57) | PTGER4SIGMAR1PTGER2 | |
| SCHEMBL12628333 | 0.77 | HDAC1 (0.58) | HDAC1HDAC6NOTUMADRB2ADRB1 | |
| SCHEMBL29572755 | 0.77 | SIGMAR1 (0.57) | PTGER4SIGMAR1PTGER2 | |
| SCHEMBL10637512 | 0.77 | SRD5A1 (0.46) | NOTUMCA1CA2CA9CA14 | |
| SCHEMBL12628340 | 0.76 | HDAC1 (0.57) | HDAC1HDAC6NOTUMADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159376-B1 | 1-(AMINOALKYLPHENYL AND AMINOALKYLBENZYL)-INDOLES AND INDOLINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-11-02 | — | — | EP | disclosed |
| EP-0159376-A1 | 1-(Aminoalkylphenyl and Aminoalkylbenzyl)-indoles and indolines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-10-30 | — | — | EP | disclosed |
| US-4532333-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1985-07-30 | — | — | US | disclosed |
| US-4448784-A | 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1984-05-15 | — | — | US | disclosed |