Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ME2 | P23368 | 1/20 | 0.86 |
| ▸ | ME1 | P48163 | 1/20 | 0.86 |
| ▸ | ME3 | Q16798 | 1/20 | 0.86 |
| ▸ | BACE1 | P56817 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14773924 | 0.86 | ME2 (0.74) | ME2ME1ME3MAPTNPC1 | |
| SCHEMBL6340096 | 0.85 | ME2 (0.73) | ME2ME1ME3MAPTNPC1 | |
| SCHEMBL9723700 | 0.83 | BACE1 (0.62) | ME2ME1ME3BACE1PDE4B | |
| SCHEMBL13141855 | 0.83 | BACE1 (0.62) | ME2ME1ME3BACE1PDE4B | |
| SCHEMBL6341773 | 0.83 | ME2 (0.63) | ME2ME1ME3BACE1MAPT | |
| SCHEMBL6341770 | 0.83 | ME2 (0.63) | ME2ME1ME3BACE1MAPT | |
| SCHEMBL2445444 | 0.82 | P2RX7 (0.65) | ME2ME1ME3PDE4BMAPT | |
| SCHEMBL13585812 | 0.81 | BACE1 (0.61) | ME2ME1ME3BACE1PDE4B | |
| SCHEMBL13569202 | 0.81 | BACE1 (0.61) | ME2ME1ME3BACE1PDE4B | |
| Bicarbonate SCHEMBL28112150 | 0.77 | CES2 (0.61) | BACE1NPC1RAB9AHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367606-B2 | Method and compositions for prevention and treatment of diabetic and aged skin | HEALOR LTD. (IL) | 2013-02-05 | — | — | US | disclosed |
| EP-2462944-A2 | Methods and compositions for prevention and treatment of diabetic and aged skin | HealOr Ltd. (IL) | 2012-06-13 | — | — | EP | disclosed |
| EP-2452691-A2 | Methods and compositions for prevention of diabetic and aged skin | HealOr Ltd. (IL) | 2012-05-16 | — | — | EP | disclosed |
| EP-2452686-A2 | Methods and compositions for prevention and treatment of diabetic and aged skin | HealOr Ltd. (IL) | 2012-05-16 | — | — | EP | disclosed |
| EP-2452687-A2 | Methods and compositions for prevention and treatment of diabetic and aged skin | HealOr Ltd. (IL) | 2012-05-16 | — | — | EP | disclosed |
| US-20110021422-A1 | METHOD AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF DIABETIC AND AGED SKIN | HEALOR LTD. (IL) | 2011-01-27 | — | — | US | disclosed |
| EP-1940440-A2 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF DIABETIC AND AGED SKIN | Healor Ltd. (IL) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007026356-A2 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF DIABETIC AND AGED SKIN | HEALOR LTD. (IL) | 2007-03-08 | — | — | WO | disclosed |