Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10113882 | 0.91 | TRPA1 (1.00) | TRPA1RXFP1TP53THRBPORCN | |
| SCHEMBL10114021 | 0.89 | TRPA1 (0.80) | TRPA1RXFP1TP53THRBPORCN | |
| SCHEMBL3787737 | 0.89 | TRPA1 (0.80) | TRPA1RXFP1TP53THRBPORCN | |
| SCHEMBL15394742 | 0.88 | TRPA1 (0.78) | TRPA1RXFP1TP53THRBPORCN | |
| SCHEMBL10114054 | 0.88 | RXFP1 (0.78) | TRPA1RXFP1TP53THRBPORCN | |
| SCHEMBL20079684 | 0.88 | TRPA1 (0.78) | TRPA1RXFP1TP53THRBPORCN | |
| SCHEMBL10113830 | 0.87 | TRPA1 (0.77) | TRPA1RXFP1TP53THRBPORCN | |
| SCHEMBL10130857 | 0.87 | TRPA1 (0.77) | TRPA1RXFP1TP53THRBPORCN | |
| SCHEMBL3826453 | 0.87 | TRPA1 (0.77) | TRPA1RXFP1TP53THRBPORCN | |
| SCHEMBL4533692 | 0.86 | RXFP1 (0.78) | TRPA1RXFP1TP53THRBPORCN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025264860-A2 | METHODS OF TREATING POST-COVID AIRWAY DISEASE | YALE UNIVERSITY (US) | 2025-12-26 | — | — | WO | claimed |
| CN-118319855-A | Preparation method of PEG-PLGA loaded TRPA1 micelle synthesis | 上海大学 | 2024-07-12 | — | — | CN | claimed |
| CN-117205319-A | Application of TRPA1 ion channel as drug target in paraquat poisoning | 中国人民解放军军事科学院军事医学研究院 | 2023-12-12 | — | — | CN | claimed |
| CN-114903995-B | Application of TRPA1 ion channel as drug target in amide herbicide poisoning | 中国人民解放军军事科学院军事医学研究院 | 2023-07-28 | — | — | CN | claimed |
| CN-115212215-A | Application of bile acid binding receptor TGR5 in treatment of diarrhea after cholecystectomy | 上海市闵行区中心医院 | 2022-10-21 | — | — | CN | claimed |
| CN-114903995-A | Application of TRPA1 ion channel as drug target in amide herbicide poisoning | 中国人民解放军军事科学院军事医学研究院 | 2022-08-16 | — | — | CN | claimed |
| CN-114712364-A | Application of transient receptor potential ankyrin 1 ion channel antagonist | 南通大学 | 2022-07-08 | — | — | CN | claimed |
| US-20110151018-A1 | METHODS OF INSECT CONTROL | BRANDEIS UNIVERSITY (US) | 2011-06-23 | — | — | US | claimed |
| US-20110144137-A1 | METHOD FOR PREVENTING OR ALLEVIATING THE NOXIOUS EFFECTS RESULTING FROM TOXICANT EXPOSURE | YALE UNIVERSITY (US) | 2011-06-16 | — | — | US | claimed |
| WO-2009152261-A1 | METHODS OF INSECT CONTROL BY INHIBITING OR MODULATING THE TRPA1 ION GATED CHANNEL OR FAMILY MEMBERS | BRANDEIS UNIVERSITY (US) | 2009-12-17 | — | — | WO | claimed |
| WO-2009137087-A2 | A METHOD FOR PREVENTING OR ALLEVIATING THE NOXIOUS EFFECTS RESULTING FROM TOXICANT EXPOSURE | YALE UNIVERSITY (US) | 2009-11-12 | — | — | WO | claimed |
| US-20260115502-A1 | ACTIVATION OF LATE RESPONSE GENES USING NEUROMODULATION | GE PREC HEALTHCARE LLC (US) | 2026-04-30 | — | — | US | disclosed |
| CN-121846022-A | Nanometer enzyme-loaded hydrogel compound and preparation method and application thereof | 川北医学院 | 2026-04-14 | — | — | CN | disclosed |
| WO-2025260159-A1 | ISOINDOLINE AND INDOLINE DERIVATIVE COMPOUNDS, COMBINATIONS, PHARMACEUTICAL COMPOSITIONS, MEDICAMENTS, USE OF THE COMPOUNDS AND METHOD OF TREATMENT OF PAIN | MICROBIOLÓGICA QUÍMICA E FARMACÊUTICA LTDA. (BR) | 2025-12-26 | — | — | WO | disclosed |
| WO-2025260150-A1 | NOVEL N-BENZYL PHTHALIMIDES FOR THE TREATMENT OF PAIN. METHODS OF PREPARATION AND THERAPEUTIC USE | MICROBIOLÓGICA QUÍMICA E FARMACÊUTICA LTDA. (BR) | 2025-12-26 | — | — | WO | disclosed |
| EP-1962855-A2 | TRPA1 INHIBITORS FOR TREATING PAIN | Hydra Biosciences, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| US-20070219222-A1 | Inhibit Transient Receptor Potential A1 (TRPA1) activity ; incontinence | HYDRA BIOSCIENCES (US) | 2007-09-20 | — | — | US | disclosed |
| US-20070219222-A1 | Inhibit Transient Receptor Potential A1 (TRPA1) activity ; incontinence | HYDRA BIOSCIENCES (US) | 2007-09-20 | — | — | US | disclosed |
| US-20070219222-A1 | Inhibit Transient Receptor Potential A1 (TRPA1) activity ; incontinence | HYDRA BIOSCIENCES (US) | 2007-09-20 | — | — | US | disclosed |
| WO-2007073505-A2 | TRPA1 INHIBITORS FOR TREATING PAIN | HYDRA BIOSCIENCES, INC. (US) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110151018-A1 | METHODS OF INSECT CONTROL | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885RXFP1 2802/4885TP53 4822/4885 |
| US-20260115502-A1 | ACTIVATION OF LATE RESPONSE GENES USING NEUROMODULATION | GCKR, ADIPOR2, GPR119 | TRPA1 2863/4885RXFP1 183/4885TP53 4687/4885 |
| US-20070219222-A1 | Inhibit Transient Receptor Potential A1 (TRPA1) activity ; incontinence | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885RXFP1 33/4885TP53 4573/4885 |
| US-20110144137-A1 | METHOD FOR PREVENTING OR ALLEVIATING THE NOXIOUS EFFECTS RESULTING FROM TOXICANT EXPOSURE | TRPA1, HRH2, HRH4 | TRPA1 1/4885RXFP1 2867/4885TP53 1382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.