Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | DDX3X | O00571 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675741 | 0.83 | AAK1 (0.42) | POLBATMLMNAHSD17B10 | |
| SCHEMBL20293692 | 0.79 | LIPE (0.39) | RAB9ANPC1LIPGLPLATM | |
| SCHEMBL1058987 | 0.78 | LIPE (0.48) | RAB9ANPC1HPGDPOLBALDH1A1 | |
| SCHEMBL3859397 | 0.78 | ALDH1A1 (0.47) | HPGDPOLBALDH1A1HIF1AKDM4E | |
| SCHEMBL4674071 | 0.78 | LPL (0.44) | LIPGLPLATMTRPA1CYP1A2 | |
| SCHEMBL2635452 | 0.76 | HIF1A (0.46) | HIF1ALIPGLPLP4HBMEN1 | |
| SCHEMBL1811614 | 0.75 | NR4A2 (0.41) | POLBALDH1A1KDM4EATMMEN1 | |
| SCHEMBL26119279 | 0.74 | LIPE (0.39) | HIF1AKDM4ELIPGLPLP4HB | |
| SCHEMBL14053701 | 0.74 | HIF1A (0.50) | HIF1ALIPGLPLP4HB | |
| SCHEMBL22777316 | 0.74 | HIF1A (0.35) | HIF1ALIPGLPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268618-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009111337-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2009-09-11 | — | — | WO | disclosed |