Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NMT1 | P30419 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10961222 | 0.86 | PKM (0.49) | PKMTRPV4TSHRGLAKMT2A | |
| SCHEMBL10638960 | 0.84 | PKM (0.51) | PKMTRPV4TSHRGLAKMT2A | |
| SCHEMBL248149 | 0.79 | NMT1 (0.50) | PKMTRPV4TSHRGLAKMT2A | |
| SCHEMBL24811430 | 0.78 | TRPV4 (0.41) | PKMTRPV4TSHRGLAKMT2A | |
| SCHEMBL28340937 | 0.75 | ACHE (0.48) | TRPV4TSHRGLAKMT2AFFAR4 | |
| SCHEMBL10639533 | 0.75 | PKM (0.41) | PKMTSHRGLAKMT2ANMT1 | |
| SCHEMBL10639539 | 0.75 | PKM (0.41) | PKMTSHRGLAKMT2ANMT1 | |
| SCHEMBL22264549 | 0.74 | GLA (0.38) | PKMTSHRGLAKMT2AALDH1A1 | |
| SCHEMBL30943706 | 0.74 | GLA (0.38) | PKMTSHRGLAKMT2AALDH1A1 | |
| SCHEMBL28017980 | 0.74 | ACHE (0.41) | PKMTSHRGLAKMT2ANMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766241-A | LOWER ACUTE TOXICITY | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-23 | — | — | US | disclosed |
| US-4607030-A | ANTIEDEMICS, HYPOTENSIVES | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-08-19 | — | — | US | disclosed |
| EP-0088345-A2 | 2-Aminomethyl-6-sulfamoylphenol derivatives, process for their preparation, their use and pharmaceutical preparations based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-09-14 | — | — | EP | disclosed |