Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17316537 | 0.84 | TSHR (0.50) | KMOHTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL19016817 | 0.84 | HTR1A (0.50) | HTR1AHTR1DHTR1BSLC6A4KCNH2 | |
| SCHEMBL9594271 | 0.82 | HTR1A (0.48) | HTR1AHTR1DHTR1BSLC6A4KCNH2 | |
| SCHEMBL8249215 | 0.81 | HTR1A (0.52) | HTR1AHTR1DHTR1BSLC6A4KCNH2 | |
| SCHEMBL4173618 | 0.80 | HTR1A (0.51) | KMOHTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL23085544 | 0.80 | RIPK1 (0.44) | KMOHTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL554626 | 0.80 | PDE3B (0.48) | KMOHTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL10929292 | 0.79 | PDE3B (0.45) | KMOHTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL10641509 | 0.79 | KMO (0.41) | KMOTSHRHTTPOLBTP53 | |
| SCHEMBL764050 | 0.78 | PARP1 (0.50) | HTR1AHTR1DHTR1BSLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272914-A2 | 6-Benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-06-29 | — | — | EP | disclosed |