Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 11/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22590446 | 0.85 | RIPK1 (0.48) | RIPK1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL22048464 | 0.81 | PARP1 (0.41) | HTR1AHTR1DHTR1BSLC6A4KCNH2 | |
| SCHEMBL26410406 | 0.81 | RIPK1 (0.42) | RIPK1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL10643228 | 0.80 | KMO (0.50) | RIPK1KMOHTR1AHTR1DHTR1B | |
| SCHEMBL30986604 | 0.78 | LMNA (0.51) | — | |
| SCHEMBL30986608 | 0.78 | LMNA (0.51) | — | |
| SCHEMBL21531332 | 0.77 | RIPK1 (0.53) | RIPK1LTB4RLTB4R2 | |
| SCHEMBL21531334 | 0.77 | RIPK1 (0.53) | RIPK1LTB4RLTB4R2 | |
| SCHEMBL81136 | 0.76 | FABP4 (0.58) | FABP4SLC6A4KCNH2TSHRDRD2 | |
| SCHEMBL17316537 | 0.74 | TSHR (0.50) | KMOHTR1AHTR1DHTR1BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4248975-A2 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2023-09-27 | — | — | EP | disclosed |
| WO-2021046407-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |