Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4945184 | 0.75 | ALDH1A1 (0.59) | TDP1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10645037 | 0.73 | GAA (0.51) | KMT2AMEN1CYP2C19ALDH1A1LMNA | |
| SCHEMBL10645403 | 0.72 | MAPT (0.51) | ALDH1A1MAPTMAPK1ALOX15GAA | |
| SCHEMBL9646362 | 0.70 | TDP1 (0.39) | TDP1NR2E3MAPT | |
| SCHEMBL10645458 | 0.70 | HDAC3 (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL10645544 | 0.70 | KDM4C (0.36) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL11007204 | 0.69 | SMN1; SMN2 (0.38) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL6923968 | 0.69 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4579585 | 0.69 | ITGB1 (0.42) | ABL1RIN1TDP1NR2E3KMT2A | |
| SCHEMBL31124620 | 0.69 | ITGB1 (0.42) | ABL1RIN1TDP1NR2E3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0095278-B1 | 5-OXO-2-PYRROLIDINEPROPANOIC ACID DERIVATIVES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| EP-0095278-A2 | 5-Oxo-2-pyrrolidinepropanoic acid derivatives and their production | WARNER-LAMBERT COMPANY (US) | 1983-11-30 | — | — | EP | claimed |
| EP-0095278-B1 | 5-OXO-2-PYRROLIDINEPROPANOIC ACID DERIVATIVES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| US-4617310-A | 5-oxo-2-pyrrolidinepropanoic acid derivatives and use as cognition activators | WARNER-LAMBERT COMPANY (US) | 1986-10-14 | — | — | US | disclosed |
| US-4559358-A | TREATING SENILITY | WARNER-LAMBERT COMPANY (US) | 1985-12-17 | — | — | US | disclosed |
| EP-0095278-A2 | 5-Oxo-2-pyrrolidinepropanoic acid derivatives and their production | WARNER-LAMBERT COMPANY (US) | 1983-11-30 | — | — | EP | disclosed |