Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | RXRB | P28702 | 3/20 | 0.36 |
| ▸ | RXRG | P48443 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647252 | 0.88 | AHR (0.50) | PARP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL10788798 | 0.85 | NPC1 (0.42) | HTR2ANPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL10646898 | 0.81 | ALDH1A1 (0.54) | HTR2AALDH1A1BRD4 | |
| SCHEMBL10789325 | 0.81 | DDB1 (0.44) | HTR2AMAOAMAOBALDH1A1 | |
| SCHEMBL28628183 | 0.80 | NPC1 (0.46) | HTR2ANPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL8919270 | 0.78 | NPC1 (0.47) | HTR2ANPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL17969062 | 0.78 | NPC1 (0.47) | HTR2ANPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL836831 | 0.77 | DRD2 (0.46) | PARP1HTR2ANPC1MAPK13MAPK12 | |
| SCHEMBL11266794 | 0.76 | NPC1 (0.46) | HTR2ANPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL11278612 | 0.76 | LMNA (0.46) | NPC1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153006-B1 | BENZOTRICYCLIC NITROGEN-CONTAINING DIONES AND A PROCESS FOR THE PRODUCTION THEREOF | WARNER-LAMBERT COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4677112-A | 1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators | WARNER-LAMBERT COMPANY (US) | 1987-06-30 | — | — | US | disclosed |
| US-4582909-A | Benzobicyclic lactam acids and derivatives as cognition activators | WARNER-LAMBERT COMPANY (US) | 1986-04-15 | — | — | US | disclosed |
| EP-0153006-A1 | Benzotricyclic nitrogen-containing diones and a process for the production thereof | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |
| EP-0151539-A2 | Benzobicyclic lactam acids, their derivatives, an intermediate in the preparation thereof and processes for the production thereof | WARNER-LAMBERT COMPANY (US) | 1985-08-14 | — | — | EP | disclosed |
| US-4530929-A | Tricyclic containing an imide group | WARNER-LAMBERT COMPANY (US) | 1985-07-23 | — | — | US | disclosed |