Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ADH5 | P11766 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10730810 | 0.89 | TBXAS1 (0.36) | TBXAS1CYP3A4BAZ2BCTSAKDM4E | |
| SCHEMBL10724660 | 0.86 | MMP2 (0.36) | TBXAS1CYP3A4BAZ2BCTSAKDM4E | |
| SCHEMBL10724974 | 0.84 | TBXAS1 (0.34) | TBXAS1CYP3A4BAZ2BCTSAKDM4E | |
| SCHEMBL10729354 | 0.84 | STING1 (0.40) | TBXAS1CYP3A4BAZ2B | |
| SCHEMBL10724289 | 0.83 | HMOX2 (0.41) | TBXAS1CYP3A4CTSAKDM4EHMOX2 | |
| SCHEMBL10730531 | 0.82 | CYP3A4 (0.35) | TBXAS1CYP3A4BAZ2BKDM4EADH5 | |
| SCHEMBL10729453 | 0.77 | TBXAS1 (0.46) | TBXAS1CYP3A4BAZ2BADH5HTT | |
| SCHEMBL10646011 | 0.77 | KMT2A (0.33) | CYP3A4KDM4EHTT | |
| SCHEMBL10726954 | 0.77 | STING1 (0.42) | TBXAS1CYP3A4BAZ2BKDM4EADH5 | |
| SCHEMBL10625333 | 0.76 | CYP3A4 (0.58) | TBXAS1CYP3A4BAZ2BADH5HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |